Biophysics for Therapeutic Protein Development - Narhi, Linda O.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2013)
Introduction -- High Throughput Biophysical Approaches to Therapeutic Protein Development -- Techniques for Higher Order Structure Determination -- Biophysical Techniques for Protein Size Distribution Analysis -- Qualification of biophysical methods for the analysis of protein therapeutics -- Application of Biophysics to the Early Developability Assessment of Therapeutic Candidates and its Application to Enhance Developability Properties -- Application of Biophysics in Formulation, Process and Product Characterization: Selected Case Studies -- Biophysical Analysis in Support of Development of Protein Pharmaceuticals -- Case Studies Applying Biophysical Techniques to Better Characterize Protein Aggregates and Particulates of Varying Size -- Investigation of Non Conformance During Protein Therapeutic Manufacturing -- Higher order structure and protein aggregate characterization of protein therapeutics: perspectives from good manufacturing practices and regulatory guidance -- Index.
Keywords: Pharmacology; Medical biochemistry; Proteins .; Biophysics; Biological physics; Pharmacology/Toxicology.; Medical Biochemistry; Protein Science; Protein-Ligand Interactions; Biological and Medical Physics, Biophysics