Cellular Ageing and Replicative Senescence - Rattan, Suresh I.S.; Hayflick, Leonard; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2016)
Preface -- Section I  History and origins --  Origins of the Hayflick system, the phenomenon and the limit -- Early testing and development of the Hayflick system -- Section II Serial passaging and progressive changes -- Slowing down of the cell cycle -- Ageing of cells in the centenarians and long-lived -- Aging of the stem cells -- Aging and senescence in the immune cells in vitro and in vivo -- Accelerated cellular aging in progeroid syndromes -- Telomere and genomic instability -- Mechanistic explanation for cellular aging in vitro: the commitment theory -- Modelling cellular aging senescence -- Section-III Regulation, and senescence -- Cell cycle checkpoints and regulators of senescence -- Oxidative stress and cellular ageing -- Biomarkers of replicative senescence revisited -- Cellular aging and tumour regulation -- Declining Protein turnover and degradation -- Section IV Modulating the system -- Stress induced premature senescence (SIPS) -- Mild stress-induced hormesis -- Food, hormones and growth factors in cellular aging -- sncRNAs in cellular aging and senescence -- Elimination of senescent cells for rejuvenation -- Section-V RECAPITULATION -- The past, present and the future of cellular aging and replicative senescence -- Index.
Keywords: Cytogenetics; Cell biology; Geriatrics; Cytogenetics; Cell Biology; Geriatrics/Gerontology.