From Molecular to Modular Tumor Therapy : Tumors are Reconstructible Communicatively Evolving Systems - Reichle, Albrecht; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 2010)
Therapy-Derived Systems Biology: A Pragmatic Communication Theory -- Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients -- Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options -- Principles of Modular Tumor Therapy -- Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation's Interpretation for Creating Systems-Directed Therapies -- Cancer and Coagulation; Focusing on Tissue Factor and Heparanase -- The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity -- Shaping Tumor Associated Macrophages: The Role of NF-?B -- The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target -- Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients? -- Systems-Relevant Molecular and Cellular Targets: Implementation of Modular 'Knowledge' -- Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins -- Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-?B -- The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment -- Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy -- Systems Biology: A Therapeutic Target for Tumor Therapy -- The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation -- Searching for the 'Metabolism' of Evolution -- Biomodulatory Therapy Approaches in Metastatic Cancer -- The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival -- Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma -- C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma -- Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer -- Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP) -- Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging -- Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis -- Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches -- Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma -- Pharmacological Considerations on Systems Biological Therapy Approaches -- Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies -- Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy -- Tumors' Systems Biology: Implications for Personalized Therapy -- A Methodological Approach to Personalized Therapies in Metastatic Cancer -- Summary -- To Be an Object in a Biological System -- From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy.
Keywords: Oncology .; Medicinal chemistry; Medicine; Cancer research; Pharmaceutical technology; Evolutionary biology; Oncology; Medicinal Chemistry; Medicine/Public Health, general; Cancer Research; Pharmaceutical Sciences/Technology.; Evolutionary Biology