Functional Selectivity of G Protein-Coupled Receptor Ligands : New Opportunities for Drug Discovery - Neve, Kim.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2009)
Theoretical and Mechanistic Aspects of Functional Selectivity -- Historical Overview of the Concept of Functional Selectivity -- Functional Selectivity: Theoretical Considerations and Future Directions -- Agonist-Selective Coupling of G Protein-Coupled Receptors -- Ligand-Selective Receptor Desensitization and Endocytosis -- Selectivity for G Protein or Arrestin-Mediated Signaling -- In Vivo Evidence for and Consequences of Functional Selectivity -- Subfamilies of Therapeutically Relevant Receptors -- Functional Selectivity at Adrenergic Receptors -- Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity -- Functional Selectivity at Serotonin Receptors -- Functional Selectivity at Dopamine Receptors -- Functional Selectivity at Receptors for Cannabinoids and Other Lipids -- Functional Selectivity at Opioid Receptors -- Functional Selectivity at Non-Opioid Peptide Receptors.
Keywords: Neurosciences; Pharmacology; Neurobiology; Neurology .; Human physiology; Neurosciences; Pharmacology/Toxicology.; Neurobiology; Neurology; Human Physiology