Experimental Cholestasis Research - Vinken, Mathieu; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Humana, 2019)
Mechanisms of Drug-Induced Cholestasis -- LC-MS/MS Analysis of Bile Acids in In Vitro Samples -- Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis -- Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function -- The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity -- In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids -- Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy -- The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis -- Measuring Apoptosis and Necrosis in Cholestatic Liver Injury -- Necrosome Formation and Necroptosis in Experimental Cholestasis -- Proteomics in Primary Biliary Cholangitis -- Transcriptomics Analysis of Cholestatic Compounds In Vitro -- Systems Microscopy of Stress Response Pathways in Cholestasis Research -- Mouse Models for Diseases in the Cholangiocyte Lineage -- Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis -- 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research -- A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis -- Zebrafish as a Model to Study Cholestatic Liver Diseases -- Set-Up and Use of HepaRG Cells in Cholestasis Research -- Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis -- Establishment of Sandwich Cultures of Primary Human Hepatocytes -- Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes -- Ex Vivo Model in Cholestasis Research -- Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies -- Use of Biliary Organoids in Cholestasis Research -- In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis.
Keywords: Pharmacology; Hepatology; Pharmacology/Toxicology.; Hepatology