Enzyme- and Transporter-Based Drug-Drug Interactions : Progress and Future Challenges - Pang, K. Sandy; Rodrigues, A. David; Peter, Raimund M.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2010)
Determinants of Drug ADME -- Enzymatic Basis of Phase I and Phase II Drug Metabolism -- Transporters: Importance in Drug Absorption, Distribution, and Removal -- ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions -- Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters -- Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances -- Methods For The Study Of Drug-Drug Interactions -- In Silico Approaches to Predict DDIs -- In Vitro Techniques to Study Drug-Drug Interactions of Drug Metabolism: Cytochrome P450 -- The In Vitro Characterization of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase -- In Vitro Techniques to Study Transporter-Based DDI -- In Vitro Techniques to Study Drug-Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters -- Use of In Vivo Animal Models to Assess Drug-Drug Interactions -- Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modeling and Simulations -- Translation of In Vitro Metabolic Data to Predict In Vivo Drug-Drug Interactions: IVIVE and Modeling and Simulations -- Absorption Models to Examine Bioavailability and Drug-Drug Interactions in Humans -- Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database© -- Web-Based Database as a Tool to Examine Drug-Drug Interactions Involving Transporters -- Impact Of Drug-Drug Interactions -- Drug Disposition and Drug-Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver -- Transporter-Based Drug-Drug Interactions and Their Effect on Distribution Volumes -- Inactivation of Human Cytochrome P450 Enzymes and Drug-Drug Interactions -- Allosteric Enzyme- and Transporter-Based Interactions -- The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug-Drug Interactions in Humans -- Herbal Supplement-Based Interactions -- Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective -- Clinical Studies of Drug-Drug Interactions: Design and Interpretation -- Toxicological Consequences of Drug-Drug Interactions -- Regulatory Aspects And Future Developments Involving DDI -- Complex Drug Interactions: Significance and Evaluation -- Drug-Drug Interactions: Communicating Post-market Drug Safety Information in the USA -- Drug-Drug Interactions: What Have We Learned and Where Are We Going?.
Keywords: Pharmacology; Analytical chemistry; Medicinal chemistry; Pharmacology/Toxicology.; Analytical Chemistry; Medicinal Chemistry