Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response - Innocenti, Federico; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2009)
Genomic Experimental Approaches in Oncology -- Toward the Realization of the Promise of Microarrays in Oncology -- Cell-Based Models to Identify Genetic Variants Contributing to Anticancer Drug Response -- Proteomic Analysis in Cancer Patients -- MicroRNAs and Discovery of New Targets -- Pharmacogenomics of the National Cancer Institute's 60-Tumor Cell Panel -- Use of Single-Nucleotide Polymorphism Array for Tumor Aberrations in Gene Copy Numbers -- Pharmacogenomics of Toxicity and Response of Chemotherapy -- Concordance Between Tumor and Germline DNA -- Epidermal Growth Factor Receptor Mutations and Sensitivity to Selective Kinase Inhibitors in Human Lung Cancer -- BCR-ABL Mutations and Imatinib Resistance in Chronic Myeloid Leukemia Patients -- Role of Thymidylate Synthase Gene Variations in Colorectal Cancer Patients -- Thiopurines in the Treatment of Childhood Acute Lymphoblastic Leukemia and Genetic Variants of the Thiopurine S-Methyltransferase Gene -- Impact of Polymorphisms on the Clinical Outcomes of Monoclonal Antibody Therapy Against Hematologic Malignancies -- DNA Repair and Mitotic Checkpoint Genes as Potential Predictors of Chemotherapy Response in Non-Small-Cell Lung Cancer -- Dihydropyrimidine Dehydrogenase (Dpyd) Gene Polymorphism: Portrait of a Serial Killer -- Impact of UDP-Glucuronosyltransferase 1A Haplotypes on Irinotecan Treatment -- Microarray Profiling in Breast Cancer Patients -- Role of the Folate-Pathway and the Thymidylate Synthase Genes in Pediatric Acute Lymphoblastic Leukemia Treatment Response -- Pharmacogenomics in Clinical Drug Development in Oncology -- Pharmacogenomics in Drug Development: A Pharmaceutical Industry Perspective -- Identification of Pharmacogenomic Biomarker Classifiers in Cancer Drug Development -- Toxicogenomics Application to Oncology Drug Development -- Strategies to Identify Pharmacogenomic Biomarkers: Candidate Gene, Pathway-Based, and Genome-Wide Approaches.
Keywords: Cancer research; Pharmacology; Human genetics; Cancer Research; Pharmacology/Toxicology.; Human Genetics