Fifty Years of Cytochrome P450 Research - Yamazaki, Hiroshi; SpringerLink (Online service) (Tokyo : Springer Japan : Imprint: Springer, 2014)
Preface -- Part 1 Cytochrome P450 History -- 1 Pioneers in the Early Years of Cytochrome P450 Research -- 2 Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes? -- 3 Fifty Years of Cytochrome P450 Research: Examples of What We Know and Don't Know -- Part 2 Structure, Function, and Practical Applications of P450 -- 4 Cytochrome P450 Dynamics -- 5 Structural and Functional Diversity of Cytochrome P450 -- 6 Oxygenation of Non native Substrates Using a Malfunction State of Cytochrome P450s -- 7 Plant Cytochrome P450s in Triterpenoid Biosynthesis: Diversity and Application to Combinatorial Biosynthesis -- 8 Mammalian and Bacterial Cytochromes P450 Involved in Steroid Hydroxylation: Regulation of Catalysis and Selectivity and Potential Applications -- 9 Neurosteroids: Regional Steroidogenesis -- 10 Whole Cell-Dependent Biosynthesis of Drug Metabolites Using Genetically Engineered Budding Yeast -- 11 Metabolic Diversity and Cytochromes P450 of Fungi -- 12 Metabolic Engineering of Flower Colour Pathways Using Cytochromes P450 -- Part 3 Gene Regulation of P450 -- 13 Aryl Hydrocarbon Receptor Suppresses Cecal Carcinogenesis -- 14 Epidermal Growth Factor Receptor: The Phenobarbital Receptor That Elicits CAR Activation Signal for P450 Induction -- 15 Steroidogenic Cytochrome P450 Gene CYP11A1: Functions and Regulation -- 16 Cooperative Regulation of Expression of Cytochrome P450 Enzymes by Aryl Hydrocarbon Receptor and Vitamin D Receptor -- Part 4 Drug Metabolism -- 17 Species, Ethnic and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes -- 18 Cytochrome P450-Depedent Change in UDP- Glucuronosyltransferase Function and Its Reverse Regulation -- 19 Control of Xeno/Endobiotics-Metabolizing Cytochrome P450s by Micro RNAs -- 20 The Pharmacogenomics of Cytochrome P450s: From Molecular to Clinical Application -- 21 Cytochrome P450 Polymorphisms of Clinical Importance -- BM Epilogue -- Index.
Keywords: Pharmaceutical technology; Medical genetics; Pharmacology; Human genetics; Pharmaceutical Sciences/Technology.; Gene Function; Pharmacology/Toxicology.; Human Genetics