GPCRs: From Deorphanization to Lead Structure Identification /

Bibliographic Details
Corporate Author:	SpringerLink (Online service)
Other Authors:	Bourne, H. (Editor), Horuk, Richard. (Editor), Kuhnke, J. (Editor), Michel, H. (Editor)
Format:	eBook
Language:	English
Published:	Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2007.
Edition:	1st ed. 2007.
Series:	Ernst Schering Foundation Symposium Proceedings, 2006/2
Subjects:	Pharmacology. Medical biochemistry. Chemoinformatics. Medical microbiology. Pharmacology/Toxicology. Medical Biochemistry. Computer Applications in Chemistry. Medical Microbiology.

Table of Contents:

G-Proteins and GPCRs: From the Beginning
Modeling GPCRs
QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications
Privileged Structures in GPCRs
Designing Compound Libraries Targeting GPCRs
Orphan Seven Transmembrane Receptor Screening
The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling
Deorphanization of G-Protein-Coupled Receptors
Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target
Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins
High Content Screening to Monitor G Protein-Coupled Receptor Internalisation
High-Throughput Lead Finding and Optimisation for GPCR Targets.

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