Leucine-Rich Repeat Kinase 2 (LRRK2) - Rideout, Hardy J.; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2017)
Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the "LRRKtosome" at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and α-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.
Keywords: Neurosciences; Neurology .; Neurosciences; Neurology