Membrane Transporters in Drug Discovery and Development : Methods and Protocols - Yan, Qing.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2010)
Membrane Transporters and Drug Development: Relevance to Pharmacogenomics, Nutrigenomics, Epigenetics, and Systems Biology -- Bioinformatics for Transporter Pharmacogenomics and Systems Biology: Data Integration and Modeling with UML -- Multidrug Resistance: Phylogenetic Characterization of Superfamilies of Secondary Carriers that Include Drug Exporters -- Targeting Drug Transporters - Combining In Silico and In Vitro Approaches to Predict In Vivo -- Methods to Evaluate Transporter Activity in Cancer -- Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR -- Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters -- A Model for Transport Studies of the Blood-Brain Barrier -- Genetic Variants in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) and Neuropsychiatric Disorders -- Equilibrium Binding and Transport by Vesicular Acetylcholine Transporter -- ABC Transporters in Ophthalmic Disease -- Imaging of Protein Translocation In Situ in Skeletal Muscle of Living Mice -- Glucose Transporters in Parasitic Protozoa -- NMR Studies of Membrane Proteins -- Site-Directed Mutagenesis in the Study of Membrane Transporters -- Xenopus laevis Oocytes -- Measurement of Intracellular pH -- Measurement of Plasma Membrane Calcium-Calmodulin-Dependent ATPase (PMCA) Activity -- Assessment of the Contribution of the Plasma Membrane Calcium ATPase, PMCA, Calcium Transporter to Synapse Function Using Patch Clamp Electrophysiology and Fast Calcium Imaging.
Keywords: Human physiology; Pharmacology; Cell membranes .; Human Physiology; Pharmacology/Toxicology.; Membrane Biology