Humanized Mice for HIV Research - Poluektova, Larisa Y.; Garcia, J. Victor; Koyanagi, Yoshio; Manz, Markus G.; Tager, Andrew M.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2014)
Mamoru Ito's Vision for the Future of Humanized Mouse Models -- Part I. Mouse genetic background and human hematopoietic stem cells biology -- Humanized Mice as Models for Human Disease -- Role of mouse innate immunity in immunodeficient mice for xenotransplantation -- Mouse genetic background and human hematopoietic stem cells biology; tips for humanization -- Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice -- Impact of the mouse IL-2Rg chain on lymphoid tissue development and human reconstitution in immunodeficient mice -- BM hematopoietic niche occupancy defect of HSC in scid mice -- Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice -- Part II. SECTION 2: Understanding of human immune cells development and function in mouse environment -- Cytokine species-specificity and humanized mice -- Human T cell biology in a mouse environment -- Thymic education of human T cells and regulatory T cell development in humanized mice -- Human B cell development in a mouse environment -- The analysis of the functions of human B and T cells in humanized NOG mice -- NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis -- Maintenance and function of human CD8+ T cells and NK cells in humanized mice -- Phenotypical and functional properties of antigen-presenting cells derived from humanized mice -- Part III: Humanized mice for HIV-1 virus biology and pathogenesis. Is it possible to address? -- Humanized mouse versus non-human primate models of HIV-1 infection -- Host factor-mediated resistance to HIV-1 infection -- Vaginal and Rectal HIV Transmission in Humanized Mice -- Oral HIV-1 Transmission in BLT Humanized Mice -- Selective infection of CD4+ memory T cells -- Development and function of human CD4+CD25+FOXP3+ regulatory T cells in humanized mouse and HIV-1 infection -- Role of TLR signaling in HIV-1-induced adaptive immune activation -- Latent HIV-1 infection of resting CD4+ T cells: Testing approaches to overcome HIV latency -- Brain HIV-1 infection modeling in humanized mice -- Part IV. Humanized mice for HIV-1-specific adaptive cellular and humoral immune responses -- Antibody-based protection against HIV infection -- B-cell responses in humanized mice:  the glass is half full -- Part V. Therapeutics developments for HIV-1 -- Species similarities and differences in pharmacokinetics and distribution of antiretroviral drugs -- Anti-Retroviral Treatment Testing in HIV-Infected Humanized Mice -- Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy -- Targeted delivery of aptamers and siRNAs for HIV prevention and therapies in humanized mice -- Zinc finger nuclease editing of hematopoietic stem cells as an anti-HIV therapy -- Hematopoietic progenitor cell transduction by a unique short hairpin RNA to chemokine receptor 5 -- Cell-based approaches for treating HIV infection -- A conditionally replicating human immunodeficiency virus in BRG-HIS mice -- Part VI. New models for other human-specific or human selective pathogens -- Dual reconstituted mice for hepatotropic pathogens -- Dengue viral pathogenesis and immune responses in humanized mice -- HIV-1 and TB: How Humanized Mice Can Help -- Epstein-Barr Virus Infection in Humanized Mice -- HTLV-1 infection of humanized NOD/SCID IL2 gc-/- and BALB/c-Rag2-/-gc-/- mouse models -- Plasmodium falciparum parasite development in humanized mice: liver and blood stages -- Part VII. New horizons in mouse humanization -- The Future is NOW for Humanized Mouse Models.
Keywords: Medical microbiology; Immunology; Virology; Medical Microbiology; Immunology; Virology