Mast Cells and Tumours : from Biology to Clinic - Ribatti, Domenico; Crivellato, Enrico; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 2011)
Introduction -- 1. The mast cell -- 1.1. A historical overview -- 1.2. Biology of mast cells -- 2. Mast cell mediators -- 2.1. Granule composition -- 2.2. Histamine and serotonin -- 2.3. Proteases -- 2.4. Lipid mediators -- 2.5. Cytokines and growth factors -- 2.6. Chemokines -- 3. The tumour cell -- 3.1. Biology of tumour cell -- 3.2. The importance of microenvironment in tumor metastasis -- 3.3. The "seed and soil" theory -- 4. Tumour angiogenesis -- 4.1. The angiogenic switch -- 4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent -- 4.3.             What is the evidence that genetic instability promotes the angiogenic switch? -- 4.4. Hypoxic regulation of tumour angiogenesis -- 4.5.  The role of pericytes in tumour angiogenesis -- 4.6.   The role of inflammatory cells in tumour angiogenesis -- 4.7.         Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis -- 4.8.  Alternative mechanisms of tumour angiogenesis -- 4.9.   Vascular cooption -- 4.10. The prognostic significance of tumour angiogenesis -- 4.11. Angiogenesis is not necessarily involved in tumour progression -- 5. Mast cells and tumours -- 5.1. Mast cells and tumour growth in humans: pro and contra -- 6. Mast cells and tumour angiogenesis -- 6.1.            Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays -- 6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis -- 6.3.           Angiogenic factors stored in mast cells -- 6.4. Mast cells and angiogenesis in human solid tumours -- 6.5. Mast cells and angiogenesis in human hematological tumours -- 7. Mast cells and tumour lymphangiogenesis -- 8. Drug affecting mast cells -- Concluding remarks and perspectives -- References.  .
Keywords: Cancer research; Oncology .; Pathology; Cell biology; Cancer Research; Oncology; Pathology; Cell Biology