High Content Screening - Taylor, D. Lansing; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2006)
to High Content Screening -- Past, Present, and Future of High Content Screening and the Field of Cellomics -- A Pharmaceutical Company User's Perspective on the Potential of High Content Screening in Drug Discovery -- Linking Microscopy and High Content Screening in Large-Scale Biomedical Research -- Instrumentation, Biological Application Software, and Sample Preparation -- Requirements, Features, and Performance of High Content Screening Platforms -- Characteristics and Value of Directed Algorithms in High Content Screening -- Characteristics and Value of Machine Learning for Imaging in High Content Screening -- Tools for Quantitative and Validated Measurements of Cells -- Automated Cell Plating and Sample Treatments for Fixed Cells in High Content Assays -- Differentiating Primary Human Cells in Rapid-Throughput Discovery Applications -- Use of the CellCard™ System for Analyzing Multiple Cell Types in Parallel -- Reagents -- Reagents to Measure and Manipulate Cell Functions -- Fluorescent Proteins and Engineered Cell Lines -- Optimizing the Integration of Immunoreagents and Fluorescent Probes for Multiplexed High Content Screening Assays -- The HaloTag™ -- Protein Labeling With FlAsH and ReAsH -- Exploiting Network Biology to Improve Drug Discovery -- Physiological Indicators of Cell Function -- The Use of siRNA to Validate Immunofluorescence Studies -- Caged Substrates Applied to High Content Screening -- Informatics and Bioinformatics -- Overview of Informatics for High Content Screening -- Large-Scale Data Management for High Content Screening -- An Integrated Biomedical Knowledge Extraction and Analysis Platform -- Visualization of High Content Screening Data -- Pathway Mapping Tools for Analysis of High Content Data -- Assays and Applications of High Content Screening -- Systems Biology in Cancer Research -- Target Validation in Drug Discovery -- High Content Screening as a Screening Tool in Drug Discovery -- Discovery of Protein Kinase Phosphatase Inhibitors -- High Content Translocation Assays for Pathway Profiling -- In Vitro Cytotoxicity Assessment -- Neurite Outgrowth in Retinal Ganglion Cell Culture.
Keywords: Cell biology; Medicinal chemistry; Cell Biology; Medicinal Chemistry