Imaging in CNS Drug Discovery and Development : Implications for Disease and Therapy - Borsook, David; Beccera, Lino R.; Bullmore, Edward; Hargreaves, Richard J.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2009)
Background -- The Challenges and Opportunities -- Imaging of CNS Systems: Importance for Drug Development -- Imaging Approaches -- Anatomical Imaging: Volumetric Analysis -- Diffusion Tensor Imaging and Drug Development -- Functional Magnetic Resonance Imaging in Drug Development -- Magnetic Resonance Imaging of Pharmacological Systems -- Molecular Imaging: Basic Approaches -- Chemical Imaging: Magnetic Resonance Spectroscopy: The Basics -- Imaging CNS Drug Action -- Animal Imaging -- Incorporating Functional MRI into Clinical Pharmacology Trials -- Imaging Placebo Responses in the Brain -- Structural Imaging of Drug Actions in Neurodegenerative Diseases -- Molecular Imaging of the CNS: Drug Actions -- Imaging CNS Disease States -- Translational MRI in CNS Drug Discovery -- In Vivo Mouse Imaging and Spectroscopy in Drug Discovery -- Neuroimaging in Understanding Chronic Pain Mechanisms and the Development of New Therapies -- Neuroimaging Human Drug Addiction -- Anxiety: Uncover Roles of Stress Related Genes by Imaging Genetics -- Imaging CNS Disease States: Alzheimer's Disease -- Brain Development and CNS Plasticity -- Imaging in CNS Disease States: PTSD -- Integrative Processes -- Integrative Processes: Neuroscience Clinical Imaging Biomarkers -- Reasons to Believe: The Potential of Imaging in CNS Drug Development.
Keywords: Pharmacology; Radiology; Biotechnology; Neurosciences; Cancer research; Pharmacology/Toxicology.; Imaging / Radiology; Biotechnology; Neurosciences; Cancer Research