Ligand-Macromolecular Interactions in Drug Discovery : Methods and Protocols - Roque, Ana Cecília A.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2010)
Reviews -- An Historical Overview of Drug Discovery -- Ligand Macromolecule Interactions: Theoretical Principles of Molecular Recognition -- X-Ray Crystallography in Drug Discovery -- Virtual Screening of Compound Libraries -- Protocols -- Combinatorial Chemistry and the Synthesis of Compound Libraries -- Ligand-Based Nuclear Magnetic Resonance Screening Techniques -- Isothermal Titration Calorimetry and Differential Scanning Calorimetry -- Adaptive Combinatorial Design of Focused Compound Libraries -- Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors -- Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays -- Small Molecule Protein Interaction Profiling with Functional Protein Microarrays -- Capillary Electrophoresis in Drug Discovery -- SPR in Drug Discovery: Searching Bioactive Compounds in Plant Extracts -- Application of Frontal Affinity Chromatography with Mass Spectrometry (FAC#x2013;MS) for Stereospecific Ligand#x2013;Macromolecule Interaction, Detection and Screening -- GPC Spin Column HPLC#x2013;ESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins -- A Scintillation Proximity Assay for Fatty Acid Amide Hydrolase Compatible with Inhibitor Screening -- A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening -- Ligand#x2013;Macromolecule Interactions in Live Cells by Fluorescence Correlation Spectroscopy.
Keywords: Pharmacology; Medicinal chemistry; Pharmacology/Toxicology.; Medicinal Chemistry