New Approaches to Drug Discovery - Nielsch, Ulrich; Fuhrmann, Ulrike; Jaroch, Stefan; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2016)
Preface -- Part 1. Historical View -- Drug discovery in the past and today.Part 2. Target Discovery -- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis -- Part 3. Lead generation and Optimization -- Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals -- Part 4. Test systems for Efficacy and Safety -- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.
Keywords: Pharmacology; Pharmacy; Medical biochemistry; Metabolism; Pharmacology/Toxicology.; Drug Safety and Pharmacovigilance; Medical Biochemistry; Metabolomics