Organic Cation Transporters : Integration of Physiology, Pathology, and Pharmacology - Ciarimboli, Giuliano; Gautron, Sophie; Schlatter, Eberhard; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2016)
Introduction to the cellular transport of organic cations -- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism -- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity -- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy -- Physiological and pathological regulation of transporters for organic cations -- Endocrine and metabolic regulation of transporters for organic cations -- Organic cation transporters (OCTs) as modulators of behavior and mood -- Organic cation transporters as modulators of neurodegeneration and neuroprotection -- Translational relevance of animal models for the study of organic cation transporter function -- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.
Keywords: Human physiology; Pharmacology; Pathology; Human Physiology; Pharmacology/Toxicology.; Pathology