Peroxisome Proliferator-Activated Receptors : Discovery and Recent Advances - Youssef, Jihan A.; Badr, Mostafa Z.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2013)
Introduction.- History of PPAR Discovery: Peroxisomes -- Peroxisomal biogenesis and diseases -- Peroxisome proliferation.- Peroxisome Proliferator-Activated Receptors: Chromosomal location and gene polymorphism -- Protein structure -- PPAR Ligands: Endogenous ligands -- Exogenous PPAR modulators -- Tissue Distribution and Versatile Functions of PPARs: Neurological functions of PPARs.- PPARs and the cardiovascular system.- PPARs in pulmonary physiology and disease.- Gastrointestinal roles of PPARs.- PPAR functions in the liver.- Roles of PPARs in the pancreas.- PPARs in the urinary tract physiology and pathophysiology.- PPARs in the reproductive system -- Bone metabolism and PPARs.- Roles of PPARs in skeletal muscle biology.- Skin PPARs.- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions: Posttranslational control of PPARs.- Mechanism of action.- Animal Models in PPAR Research.- Safety of PPAR Agonists.- The Future of PPAR Research.
Keywords: Biochemistry; Proteins .; Biochemistry, general; Receptors