Proprotein Convertases - Mbikay, Majambu; Seidah, Nabil G.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2011)
On the Discovery of Precursor Processing -- The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity -- The Proprotein Convertases, 20 Years Later -- Insights from Bacterial Subtilases into the Mechanisms of Intramolecular Chaperone-Mediated Activation of Furin -- The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression -- In Vitro Assay for Protease Activity of Proprotein Convertase Subtilisin Kexins (PCSKs): An Overall Review of Existing and New Methodologies -- Inhibitor Screening of Proprotein Convertases Using Positional Scanning Libraries -- Analyses of PCSK9 Post-Translational Modifications Using Time-of-Flight Mass Spectrometry -- The Molecular Biology of Furin-Like Proprotein Convertases in Vascular Remodelling -- Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells -- Regulation of 7B2 mRNA Translation: Dissecting the Role of Its 5'-Untranslated Region -- Analysis of Epigenetic Alterations to Proprotein Convertase Genes in Disease -- Genetic and Functional Characterization of PCSK1 -- Prohormone Processing in Zebrafish -- Use of Zebrafish and Knockdown Technology to Define Proprotein Convertase Activity -- Characterization of Impaired Processing of Neuropeptides in the Brains of Endoproteases Knockout Mice -- Quantitative Peptidomics of Mice Lacking Peptide-Processing Enzymes -- A Proteomic Protocol to Identify Physiological Substrates of Proprotein Convertases -- Neurophenotyping Genetically-Modified Mice for Social Behavior.
Keywords: Biochemistry; Enzymology; Biochemistry, general; Enzymology