Mutant p53 and MDM2 in Cancer - Deb, Swati Palit; Deb, Sumitra; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 2014)
p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer -- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis -- p53 mutation in the genesis of metastasis -- Structural studies on mechanisms to activate mutant p53 -- Mutant p53 and the response to chemotherapy and radiation -- The p53-MDM2 loop: a critical juncture of stress response -- Mechanisms of mutant p53 stabilization in cancer -- Crosstalk between Mdm2, p53 and HIF-1α: distinct responses to oxygen stress and implications for tumour hypoxia -- MDM2 overexpression, activation of signaling networks, and cell proliferation -- p53-independent effects of MDM2 -- Splice variants of MDM2 in oncogenesis -- MDM2 and MDMX involvement in human cancer -- Targeting the p53-MDM2- MDMX loop for cancer therapy -- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ) -- The role of tumor suppressor p53 in the antioxidant defense and metabolism -- Lung cancer stem cells, p53 mutations and MDM2.
Keywords: Cancer research; Cell biology; Oncology .; Cancer Research; Cell Biology; Oncology