Redox-Active Therapeutics - Batinić-Haberle, Ines.; Rebouças, Júlio S.; Spasojević, Ivan.; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2016)
Part 1. Pathophysiological Roles of Superoxide Dismutases (SOD) -- Superoxide and the Superoxide Dismutases: An Introduction by Irwin Fridovich -- The Discovery of Superoxide Dismutase and Its Role in Redox Biology -- Manganese Superoxide Dismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer -- Regulation of the Cellular Redox Environment by Superoxide Dismutases, Catalase and Glutathione Peroxidases During Tumor Metastasis -- Superoxide Dismutase Family of Enzymes in Brain Neurogenesis and Radioprotection -- Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment -- Part 2. Redox-Active Therapeutics - Design and Mechanisms of Action -- Mimicking SOD, Why and How: Bio-Inspired Manganese Complexes as SOD Mimics -- Mn Porphyrin-Based Redox-Active Therapeutics -- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mn porphyrins as Redox Modulators -- Nitrones as Potent Anticancer Therapeutics -- Salen Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through Modulation of Tissue Environment -- Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs -- Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism -- HNO/Thiol Biology as a Therapeutic Target -- Part 3. Redox-Active Therapeutics in Cancer -- Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents -- Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells -- Targeted Therapy for Malignant Brain Tumors -- Redox Therapeutics in Breast Cancer: Role of SOD Mimics -- Anticancer Action of Mn porphyrins in Head and Neck Cancers -- Redox-based Therapeutic Strategies in the Treatment of Skin Cancers -- Role of Oxidative Stress in Erectile Dysfunction after Prostate Cancer Therapy -- Theranostic Nanoconjugates of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy -- Part 4. Redox-Active Therapeutics in Other Diseases -- Quantum Dots in Photodynamic Therapy -- Metalloporphyrins in CNS injuries -- The Contribution of Nitroxidative Stress to Pathophysiological Pain and Opioid Analgesic Failure -- Amyotrophic Lateral Sclerosis - Present Understanding of the Role of SOD -- Redox Regulation and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral Sclerosis -- Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure -- Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes -- Redox-Active Metal Complexes in Trypanosomatids.
Keywords: Oxidative stress; Enzymology; Cancer research; Oxidative Stress; Enzymology; Cancer Research