Systems Biology of Alzheimer's Disease - Castrillo, Juan I.; Oliver, Stephen G.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Humana, 2016)
Alzheimer's as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks -- Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease -- The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease -- Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing -- Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models -- Advanced Optical Super-Resolution Method and Techniques for the Study of β-Amyloid Aggregation In Vitro and In Vivo -- Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease -- LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells -- Advanced Mitochondrial Respiration Assay for Evaluation of Mitochondrial Dysfunction in Alzheimer's Disease -- Analysis of Microglial Proliferation in Alzheimer's Disease -- Yeast as a Model for Alzheimer's Disease: Latest Studies and Advanced Strategies -- Yeast as a Model for Studies on Aβ Aggregation Toxicity in Alzheimer's Disease, Autophagic Responses, and Drug Screening -- Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease -- Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models -- Gene Expression Studies on Human Trisomy 21 iPSCs and Neurons: Towards Mechanisms Underlyi ng Down's Syndrome and Early Alzheimer's Disease-Like Pathologies -- Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease -- Next Generation Sequencing in Alzheimer's Disease -- Pooled-DNA Sequencing for Elucidating New Genomic Risk Factors, Rare Variants Underlying Alzheimer's Disease -- New Genome-Wide Methods for Elucidation of Candidate Copy Number Variations (CNVs) Contributing to Alzheimer's Disease Heritability -- RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer's Disease -- Systems Biology Approaches to the Study of Biological Networks Underlying Alzheimer's Disease: Role of miRNAs -- The Emerging Role of Metalloproteomics in Alzheimer's Disease Research -- Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation -- Advanced Shotgun Lipidomics for Characterization of Altered Lipid Patterns in Neurodegenerative Diseases and Brain Injury -- AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis -- A Computational Network Biology Approach to Uncover Novel Genes Related to Alzheimer's Disease -- Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans -- Characterization of Genetic Networks Associated with Alzheimer's Disease -- Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer's Disease -- The SDREM Method for Reconstructing Signaling and Regulatory Response Networks: Applications for Studying Disease Progression -- Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease -- Plasma Proteomics Biomarkers in Alzheimer's Disease: Latest Advances and Challenges -- A Practical Guide For Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology.
Keywords: Neurosciences; Neurosciences