The Neuropathology of Huntington's Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy - Rüb, Udo.; Vonsattel, Jean Paul G.; Heinsen, Helmut; Korf, Horst-Werner.; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2015)
1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington's disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington's disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington's disease -- 7. Widespread brainstem neurodegeneration in Huntington's disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington's disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington's disease -- 10. Pathological nerve cell alterations in Huntington's disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
Keywords: Neurosciences; Human genetics; Pathology; Neurosciences; Human Genetics; Pathology