Stem Cell-Derived Models in Toxicology - Clements, Mike.; Roquemore, Liz.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Humana, 2017)
Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the "Proclinical Space" -- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk -- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology -- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes -- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential -- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions -- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems -- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes -- Decoding Ca2+ Signals as a Non-Electrophysiological Method for Assessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes -- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes -- Edge Detection for Contractility Measurements with Cardiac Spheroids -- Contractile Force Readout of hESC-Cardiomyocytes -- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models -- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes -- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA) -- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies.
Keywords: Pharmacology; Pharmacology/Toxicology.