Spotlight on Familial and Hereditary Gastric Cancer - Corso, Giovanni; Roviello, Franco; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 2013)
Foreword -- Preface.-I General Issues -- Historical overview of familial gastric cancer -- Frequency of familial gastric cancer -- The family cancer database.- II Genetics and Epigenetics -- CDH1 gene, structure and function -- E-cadherin germline mutation -- Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression -- Germline missense mutants in hereditary diffuse gastric cancer -- Alternative mechanisms to germline CDH1 mutations in hereditary diffuse gastric cancer -- Beyond CDH1 mutation-causes of hereditary gastric cancer -- Non-CDH1-associated familial gastric cancer and epigenetics factors.-III Pathology -- Hereditary diffuse gastric cancer and lobular breast carcinoma -- Pathology of hereditary diffuse gastric cancer.-IV Management -- Clinical criteria for familial gastric cancer definition -- Prophylactic total gastrectomy in CDH1 germline mutation carrier -- Gastric cancer in other inherited syndromes -- Clinical management of familial gastric cancer.- Appendix.- Index.
Keywords: Cancer research; Medicine; Gastroenterology .; Human genetics; Cancer Research; Biomedicine, general; Gastroenterology; Human Genetics