Serotonin and Sleep: Molecular, Functional and Clinical Aspects - Monti, Jaime M.; Pandi-Perumal, S. R.; Jacobs, Barry L.; Nutt, David J.; SpringerLink (Online service) (Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2008)
Evolution of concepts -- Changing concepts on the role of serotonin in the regulation of sleep and waking -- The dorsal raphe nucleus and median raphe nucleus: organization and projections -- Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus -- Efferent and afferent connections of the dorsal and median raphe nuclei in the rat -- Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states -- Serotonin receptors -- Localization of 5-HT receptors in the mammalian cortex -- Molecular biology of 5-HT receptors -- Electrophysiology of serotonergic neurons and the regulation of serotonin release -- Brain serotonergic neuronal activity in behaving cats -- Electrophysiological studies on serotonergic neurons and sleep -- Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons -- Regulation of serotonin release by inhibitory and excitatory amino acids -- Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system -- Serotonin receptors and the regulation of behavioural state -- Serotonin and dreaming -- Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking -- Mechanisms involved in the inhibition of REM sleep by serotonin -- Effect of 5-HT2A/2B/2C receptor agonists and antagonists on sleep and waking in laboratory animals and humans -- Effect of the selective activation of serotonin 5-HT3 receptors on sleep and waking -- 5-HT7 receptor modulation of sleep patterns -- Sleep and waking in mutant mice that do not express various proteins involved in serotonergic neurotransmission such as the serotonergic transporter, monoamine oxidase A, and 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT7 receptors -- Circadian control by serotonin and melatonin receptors: Clinical relevance -- Serotonergic mechanisms contributing to arousal and alerting -- Relevance of serotonin to clinical disorders and drug actions -- Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control -- Obstructive sleep apnea: The potential for serotonergic pharmacotherapies -- The effects of antidepressant drugs and 5-HT1A agonists on human sleep -- The effect of typical and atypical antipsychotic drugs on sleep of schizophrenic patients.
Keywords: Pharmacology; Molecular biology; Human physiology; Neurosciences; Pharmacology/Toxicology.; Molecular Medicine; Human Physiology; Neurosciences