Structure-Based Drug Discovery - Tari, Leslie W.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2012)
The Utility of Structural Biology in Drug Discovery -- Genetic Construct Design and Recombinant Protein Expression for Structural Biology -- Purification of Proteins for Crystallographic Applications -- Protein Crystallization for Structure-Based Drug Design -- X-Ray Sources and High-Throughput Data Collection Methods -- The Use of Molecular Graphics in Structure-Based Drug Design -- Crystallographic Fragment Screening -- The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase -- Leveraging Structural Information for the Discovery of New Drugs: Computational Methods -- Chemical Informatics - Using Molecular Shape Descriptors in Structure-Based Drug Design -- Accounting for Solvent in Structure-Based Drug Design -- Structure-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein -- Application of SBDD to the Discovery of New Antibacterial Drugs -- Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering -- A Medicinal Chemistry Perspective on Structure-Based Drug Design and Development.
Keywords: Pharmacology; Medicinal chemistry; Pharmacology/Toxicology.; Medicinal Chemistry