Systems Pharmacology and Pharmacodynamics - Mager, Donald E.; Kimko, Holly H.C.; SpringerLink (Online service) (Cham : Springer International Publishing : Imprint: Springer, 2016)
Role of Systems Modeling in Regulatory Drug Approval -- Quantitative Systems Pharmacology: Applications and Adoption in Drug Development -- Systems Pharmacology: An Overview -- Discrete dynamic modeling: a network approach for systems pharmacology -- Kinetic Models of Biochemical Signaling Networks -- Mechanistic Models of Physiological Control Systems -- Foundations of Pharmacodynamic Systems Analysis -- Direct, Indirect, and Signal Transduction Response Modeling -- Irreversible Pharmacodynamics -- Feedback Control Indirect Response Models -- Nonlinear Mixed Effects Modeling in Systems Pharmacology -- Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data -- Multi-Scale Modeling of Drug Action in the Nervous System -- Mechanistic Modeling of Inflammation -- Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities -- Translational Modeling of Antibacterial Agents -- Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges -- Using Systems Pharmacology to Advance Oncology Drug Development -- Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.
Keywords: Pharmaceutical technology; Biomathematics; Medical biochemistry; Pharmaceutical Sciences/Technology.; Mathematical and Computational Biology; Medical Biochemistry