Transformative Concepts for Drug Design: Target Wrapping - Fernandez, Ariel; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2010)
Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy -- Wrapping Defects and the Architecture of Soluble Proteins -- Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins -- Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design -- Under-Wrapped Proteins in the Order-Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation -- Evolution of Protein Wrapping and Implications for the Drug Designer -- Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence -- Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects -- Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways -- Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact -- Inducing Folding By Crating the Target -- Wrapper Drugs as Therapeutic Editors of Side Effects -- Wrapper Drugs for Personalized Medicine -- Last Frontier and Back to the Drawing Board: Protein-Water Interfacial Tension in Drug Design.
Keywords: Biomedical engineering; Medicinal chemistry; Biophysics; Biological physics; Cancer research; Biomedical Engineering and Bioengineering; Medicinal Chemistry; Biological and Medical Physics, Biophysics; Cancer Research