Translation and Its Regulation in Cancer Biology and Medicine - Parsyan, Armen; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 2014)
Preface -- Introduction -- PART I. TRANSALATION MACHINERY IN CANCER -- Mechanism of Translation in Eukaryotes -- Diverse Mechanisms of Translation Regulation and Their Role in Cancer -- eIF4E and Its Binding Proteins -- RNA Helicases and Their Cofactors -- PDCD4 -- eIF4G -- eIF3 -- The eIF2 Complex and eIF2α -- eIF5A -- eIF6 -- Translation Elongation -- Ribosomes -- Current and Emerging Therapies Targeting Translation -- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER -- mTOR and Regulation of Translation -- Ribosomal Protein S6 and S6 Kinases -- eIF4E Phosphorylation Downstream of MAPK Pathway -- PART III. CELL FATE AND TRANSLATION IN CANCER -- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells -- Translation and Apoptosis in Cancer -- Translation in Cancer at Hypoxia -- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES -- Melanoma and Non-Melanoma Skin Cancers -- Sarcomas -- Hematological Malignancies and Premalignant Conditions -- Brain Tumors -- Head and Neck Cancers -- Breast Cancer -- Cancers of the Respiratory System -- Gastric and Esophageal Cancers -- Colorectal Cancers -- Hepatic, Pancreatic and Biliary Cancers -- Pancreatic Neuroendocrine Tumors -- Gynecologic Cancers -- Prostate Cancer -- Cancers of the Urinary System -- List of Abbreviations.
Keywords: Cancer research; Oncology .; Cell biology; Molecular biology; Biochemistry; Medicine; Cancer Research; Oncology; Cell Biology; Molecular Medicine; Biochemistry, general; Biomedicine, general