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160926s2016 gw | s |||| 0|eng d |
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|a 9783319338262
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| 024 |
7 |
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|a 10.1007/978-3-319-33826-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Validation of Alternative Methods for Toxicity Testing /
|c edited by Chantra Eskes, Maurice Whelan.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
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| 300 |
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|a XX, 407 p. 44 illus., 40 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Advances in Experimental Medicine and Biology,
|v 856
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| 505 |
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|a Introduction -- Validation in support of internationally harmonised OECD Test Guidelines for assessing the safety of chemicals -- Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals -- Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools -- Practical aspects of designing and conducting validation studies involving multi-study trials -- Validation of computational methods -- Implementation of New Test Methods into Practical Testing -- Pathway Based Toxicology and Fit-for-Purpose Assays -- Evidence-based toxicology -- Validation of transcriptomics-based in vitro methods -- Ensuring the quality of stem cell-derived in vitro models for toxicity testing -- Validation of bioreactor and human-on-a-chip devices for chemical safety assessment -- Integrated approaches to testing and assessment -- International harmonization and cooperation in the validation of alternative methods -- Evolving the principles and practice of validation for new alternative approaches to toxicity testing. .
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| 650 |
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|a Pharmaceutical technology.
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| 650 |
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|a Molecular biology.
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| 650 |
1 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 700 |
1 |
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|a Eskes, Chantra.
|e editor.
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| 700 |
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|a Whelan, Maurice.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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