p53 in the Clinics - Hainaut, Pierre; Olivier, Magali; Wiman, Klas G.; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2013)
Foreword -- p53 activities and the hallmarks of cancer -- The inheritance of p53 -- p53: Guardian of the metabolome -- The p53 family and stem cell biology -- Mutant p53-driven tumorigenesis -- Humanized p53 mouse models -- p53 models for mammary carcinogenesis -- TP53 somatic mutations: Prognostic and predictive value in human cancers -- Assessing TP53 status in human tumors - lessons from breast cancer -- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome -- TP53 gene therapy -- Upstream targets in the p53 pathway -- p53-reactivating molecules as research tools and anti-cancer drugs -- Restoring mutant p53 activity -- p53-immunotherapy of cancer -- Designing p53 trials: a surgical oncologist view -- p53 in the clinic: a pathologist view -- p53 in genetic counseling -- Index.
Keywords: Cancer research; Pharmacology; Cancer Research; Pharmacology/Toxicology.