cGMP: Generators, Effectors and Therapeutic Implications - Schmidt, Harald H. H. W.; Hofmann, Franz B.; Stasch, Johannes-Peter.; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2009)
Basic Generators and Effectors -- A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases -- Biochemistry of Soluble Guanylate Cyclase -- Genetic Mouse Models of the NO Receptor 'Soluble' Guanylyl Cyclases -- Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases -- Phosphodiesterases in the Central Nervous System -- Structural and Biochemical Aspects of Tandem GAF Domains -- Cyclic Nucleotide-Gated Channels -- cGMP Regulated Protein Kinases (cGK) -- cGK Substrates -- Biochemical Detection of cGMP From Past to Present: An Overview -- Novel Techniques for Real-Time Monitoring of cGMP in Living Cells -- Pharmacology of cGMP -- NO and sGC-Stimulating NO Donors -- NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators -- NO- and Haem-Independent Soluble Guanylate Cyclase Activators -- Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications -- Cyclic GMP-Hydrolyzing Phosphodiesterases -- cGMP-Dependent Protein Kinase Modulators -- cGMP-Dependent Protein Kinase as a Modifier of Behaviour -- Clinical Applications -- cGMP in the Vasculature -- Modulating cGMP to Treat Lung Diseases -- Modulation of cGMP in Heart Failure: A New Therapeutic Paradigm -- Erectile Dysfunction and Lower Urinary Tract -- cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells -- cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour.
Keywords: Biochemistry; Pharmacology; Medical biochemistry; Human physiology; Molecular biology; Biochemistry, general; Pharmacology/Toxicology.; Medical Biochemistry; Human Physiology; Molecular Medicine