Integration of Pharmaceutical Discovery and Development Case Histories - Borchardt, Ronald T.; Freidinger, Roger M.; Sawyer, Tomi K.; Smith, Philip L.; SpringerLink (Online service) (New York, NY : Springer US : Imprint: Springer, 1998)
Renin Inhibitors -- The Discovery and Development of Angiotensin II Antagonists -- Development of an Orally Active Tripeptide Arginal Thrombin Inhibitor -- Discovery and Development of an Endothelin a Receptor-Selective Antagonist PD 156707 -- Endothelin Receptor Antagonists -- LHRH Antagonists -- LHRH Agonists -- Discovery and Development of Somatostatin Agonists -- Factors Impacting the Delivery of Therapeutic Levels of Pyrone-Based HIV Protease Inhibitors -- The Integration of Medicinal Chemistry, Drug Metabolism, and Pharmaceutical Research and Development in Drug Discovery and Development -- De Novo Design and Discovery of Cyclic HIV Protease Inhibitors Capable of Displacing the Active-Site Structural Water Molecule -- Discovery and Development of the BHAP Nonnucleoside Reverse Transcriptase Inhibitor Delavirdine Mesylate -- Famciclovir -- The Use of Esters as Prodrugs for Oral Delivery of ?-Lactam Antibiotics -- Hematoregulators -- Discovery and Development of GG745, a Potent Inhibitor of Both Isozymes of of 5?-Reductase -- Discovery of a Potent and Selective ?1A Antagonist -- Discovery of Bioavailable Inhibitors of Secretory Phospholipase A2 -- The Anxieties of Drug Discovery and Development -- CI-1015 -- Orally Active Nonpeptide CCK-A Agonists -- Orally Active Growth Hormone Secretagogues -- Dorzolamide, a 40-Year Wait -- Discovery and Development of Novel Melanogenic Drugs.
Keywords: Animal physiology; Biochemistry; Animal Physiology; Biochemistry, general