|
|
|
|
| LEADER |
02526nam a22003135i 4500 |
| 001 |
978-0-387-28500-9 |
| 005 |
20191026172413.0 |
| 007 |
cr nn 008mamaa |
| 008 |
100301s2006 xxu| s |||| 0|eng d |
| 020 |
|
|
|a 9780387285009
|
| 024 |
7 |
|
|a 10.1007/0-387-28500-8
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
4 |
|a The Proteasome in Neurodegeneration
|c edited by Leonidas Stefanis, J. N. Keller.
|
| 250 |
|
|
|a 1st ed. 2006.
|
| 260 |
# |
# |
|a New York, NY :
|b Springer US :
|b Imprint: Springer,
|c 2006.
|
| 300 |
|
|
|a XV, 306 p.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 505 |
0 |
|
|a Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS) -- Yeast Proteasome Structure and Biogenesis -- Ubiquitin-Proteasome System in the Central Nervous System -- Protein Aggregation, Inclusion Formation and Ups Function -- Protein Aggregation and the UPS: A Two-Way Street -- The Impact of Inclusion Formation on Cell Survival -- Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells -- Oxidative Stress and Ups Function -- The Proteasome: Source and a Target of Oxidative Stress? -- Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction -- Proteasome and Neuronal Cell Death and Survival -- Role of the Ubiquitin Proteasome System During Neuronal Cell Death -- Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition -- Models of Dysfunction of the UPS and the Proteasome -- Pharmacological and Molecular Models of Proteasomal Dysfunction -- The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1 -- The UPS in Neurodegenerative Diseases and Aging -- Parkinson's Disease and Related Disorders -- Ubiquitination by Parkin - Implications in Parkinson's Disease -- The Ups in Neurodegenerative Diseases and Aging Huntington's Disease -- Frameshift Mutant Ubiquitin in Alzheimer's Disease and Other Neurodegenerative Disorders -- Motor Neuron Disease -- The Paradoxical Role of Proteasomes in Prion Disorders -- Aging and the Proteasome.
|
| 650 |
|
0 |
|a Neurosciences.
|
| 650 |
|
0 |
|a Cell biology.
|
| 650 |
1 |
4 |
|a Neurosciences.
|
| 650 |
2 |
4 |
|a Cell Biology.
|
| 700 |
1 |
|
|a Stefanis, Leonidas.
|e editor.
|
| 700 |
1 |
|
|a Keller, J. N.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 856 |
4 |
0 |
|u https://doi.org/10.1007/0-387-28500-8
|