Prodrugs Challenges and Rewards - Stella, Valentino; Borchardt, Ronald; Hageman, Michael; Oliyai, Reza.; Maag, Hans.; Tilley, Jefferson; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 2007)
A Case for Prodrugs -- A Case for Prodrugs -- Problems Addressable by Prodrugs -- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs -- Topical Delivery Using Prodrugs -- Prodrug approaches to ophthalmic drug delivery -- Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery -- Prodrugs and Parenteral Drug Delivery -- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics -- Prodrugs to Reduce Presystemic Metabolism -- Controlled Release - Small Molecules -- Controlled Release - Macromolecular Prodrugs -- Controlled Release - Proenzymes -- Targeting - Theoretical and Computational Models -- Targeting - Cancer - Small Molecules -- Monoclonal Antibody Drug Conjugates for Cancer Therapy -- Antibody-Directed Enzyme Prodrug Therapy -- Prodrugs for Liver-targeted Drug Delivery -- Prodrug Approaches for Drug Delivery to the Brain -- Lymphatic Absorption of Orally Administered Prodrugs -- Colonic Delivery -- Functional Group Approach to Prodrugs -- Prodrugs of Carboxylic Acids -- Prodrugs of Alcohols and Phenols -- Prodrugs of Amines -- Prodrugs of Amides, Imides and Other NH-acidic Compounds -- Prodrugs of Benzamidines -- Prodrugs of Phosphonates, Phosphinates, and Phosphates -- Functional Group Approaches to Prodrugs: Functional Groups in Peptides -- Macromolecular Prodrugs of Small Molecules -- Miscellaneous Functional Groups -- Prodrugs - Preclinical and Clinical Considerations -- Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues -- Formulation Challenges of Prodrugs -- Safety Assessment of Prodrugs -- Toxicological Issues with Pivalate Prodrugs -- Case Studies -- Case Study: Adefovir Dipivoxil: An Oral Prodrug of Adefovir -- Case Study: Amifostine: (Ethyol®) -- Case Study: Capecitabine: A Prodrug of 5-Fluorouracil -- Case Study: Cefditoren Pivoxil: An Oral Prodrug of Cefditoren -- Case Study: Cefuroxime Axetil: An Oral Prodrug of Cefuroxime -- Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin -- Case Study: Enalapril: A Prodrug of Enalaprilat -- Case Study: Famciclovir: A Prodrug of Penciclovir -- Case Study: Fosamprenavir: A Prodrug of Amprenavir -- Case Study: Fosinopril -- Case Study: Fosphenytoin: A Prodrug of Phenytoin -- Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN-38 -- Case Study: Latanoprost: Isopropylester of a Prostaglandin F2? Analog -- Case Study: Moexipril Hydrochloride: A Prodrug of Moexiprilat -- Case Study: Mycophenolate Mofetil -- Case Study: Olmesartan Medoxomil: A Prodrug of Olmesartan -- Case Study: Omeprazole (Prilosec®) -- Case Study: Oseltamivir: An Orally Bioavailable Ester Prodrug of Oseltamivir Carboxylate -- Case Study: Parecoxib: A Prodrug of Valdecoxib -- Case Study: Tenofovir Disoproxil Fumarate: An Oral Prodrug of Tenofovir -- Case Study: Travoprost: A Potent PGF2? Analog -- Case Study: Valacyclovir: A Prodrug of Acyclovir -- Case Study: Valganciclovir: A Prodrug of Ganciclovir -- Case Study: Vantin: A Prodrug of Cefpodoxime -- Case Study: Ximelagatran: A Double Prodrug of Melagatran.
Keywords: Pharmacology; Pharmacology/Toxicology.