Lipoxygenases and their Metabolites Biological Functions - Nigam, Santosh; Pace-Asciak, Cecil R.; SpringerLink (Online service) (New York, NY : Springer US : Imprint: Springer, 1999)
1. Introductory Remarks: Historical Roots and Contemporary Aspects of Lipoxygenase Research -- I: Enzymology, Molecular Biology, and Biological Functions of Mammalian Lipoxygenases -- 2. Mammalian 15-Lipoxygenases: Enzymatic Properties and Biological Implications -- 3. Molecular Cloning of a Second Human 15S-Lipoxygenase and Its Murine Homologue, an 8S-Lipoxygenase: Their Relationship to Other Mammalian Lipoxygenases -- 4. Arachidonate 12-Lipoxygenase Isozymes -- 5. Expression of Leukocyte-Type 12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits -- 6. Lipoxygenase Gene Disruption Studies: Status and Applications -- II: Metabolic Regulation of Lipoxygenases: Lipoxygenase Inhibitors -- 7. The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain -- 8. Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions -- 9. Effect of 15-HETE on the 5-Lipoxygenase Pathway in Neutrophils: Genuine Inhibitor or Alternative Substrate? -- 10. Adenosine: An Endogenous Inhibitor of Arachidonic Acid Release and Leukotriene Biosynthesis in Human Neutrophils -- 11. Pharmacological Aspects of 5-Lipoxygenase Inhibition -- III: Products of the Lipoxygenase Pathways and Their Receptors -- 12. The Hepoxilins: A Review -- 13. Aspirin-Triggered 15-Epi-Lipoxin A4 and Stable Analogs of Lipoxin A4 Are Potent Inhibitors of Acute Inflammation: Receptors and Pathways -- 14. Modulation of LTB4 Receptor in T-Lymphocytes by Lipoxin A4 (LXA4) and Its Role in Delayed-Type Hypersensitivity -- 15. Receptors for Cysteinyl-Leukotrienes in Human Cells -- 16. Cysteinyl-Leukotrienes and the Human Lung -- 17. 12(S)-HETE in Cancer Metastasis -- 18. A 12(S)-EETE Receptor in Lewis Lung Carcinoma Cells -- 19. Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression through Direct Binding to Peroxisome Proliferator-Activated Receptors -- 20. Biogenesis and Biological Function of Marine Algal Oxylipins -- Contributors.
Keywords: Biochemistry; Pharmacology; Biochemistry, general; Pharmacology/Toxicology.