Molecular Radiation Biology The Action of Ionizing Radiation on Elementary Biological Objects - Dertinger, Hermann; Jung, Horst; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Springer, 1970)
1. Introduction -- 1.1. Historical Survey -- 1.2. Dose-Response Curves and Special Aspects of Radiation Action -- 1.3. The Temporal Stages of Radiation Action -- 1.4. The Significance of Molecular Radiation Biology -- 1.5. An Introduction to Molecular Radiation Biology -- References -- 2. The Hit Theory -- 2.1. Basic Concepts -- 2.2. Single and Multiple Hit Phenomena -- 2.3. Dose-Response Curves of Multiple Target Systems -- 2.4. The Influence of Biological Variability on the Form of Dose-Response Curves -- 2.5. The "Relative Steepness" of the Dose-Response Curve -- 2.6. Possibilities of Deception by Single-Hit Curves -- References -- 3. The Stochastics of the Action of Radiation -- 3.1. Kinetic Interpretation of the Dose-Response Curve -- 3.2. Multi-Hit Curves -- 3.3. Reverse Processes -- 3.4. A Formalistic Description of Dose-Response Curves -- 3.5. Dose-Response Curves of Colony Formation -- References -- 4. Primary Processes of Energy Absorption -- 4.1. X- and Gamma-Radiation -- 4.2. Neutrons -- 4.3. Charged Particles -- 4.4. Uptake of Energy by Molecules -- 4.5. The Energy Distribution of Secondary Electrons -- 4.6. Energy Deposited per Primary Interaction -- References -- 5. Target Theory and Action Cross Section -- 5.1. Establishment of a Rigid Concept of a "Hit" -- 5.2. Target Theory -- 5.3. Theory of the Action Cross Section -- 5.4. Relative Biological Effectiveness -- References -- 6. Direct and Indirect Action of Radiation -- 6.1. The Direct Effect -- 6.2. Indirect Effect in Solutions -- 6.3. Indirect Effect in Cells -- 6.4. Indirect Effect in the Dry State -- 6.5. Protective and Sensitizing Agents -- References -- 7. The Temperature Effect -- 7.1. Experimental Observations -- 7.2. Temperature Effect and the Indirect Action of Radiation. -- 7.3. LET-Dependence of the Temperature Effect -- 7.4. The "Thermal Spike" Model -- References -- 8. The Oxygen Effect -- 8.1. The Oxygen Effect in Macromolecules -- 8.2. An Oxygen Effect Hypothesis -- 8.3. The Oxygen Effect in Bacteria -- 8.4. Oxygen Effect and LET -- References -- 9. The Action of Radiation on Enzymes: The Example of Ribonuclease -- 9.1. Structure and Function of Ribonuclease -- 9.2. Inactivation Kinetics -- 9.3. Radiation-Induced Radicals -- 9.4. Changes in Irradiated Enzyme Molecules -- 9.5. Separation and Identification of Irradiation Products -- 9.6. Amino Acid Analysis -- 9.7. Mechanisms of Inactivation -- References -- 10. Physico-Chemical Changes in Irradiated Nucleic Acids -- 10.1. The Structure of DNA -- 10.2. Radiation-Induced Radicals -- 10.3. Chemical Changes in Irradiated DNA -- 10.4. Breaks in the Polynucleotide Chains -- 10.5. Intermolecular Cross-Linking -- 10.6. Rupture of Hydrogen Bonds -- References -- 11. Inactivation of Nucleic Acid Functions -- 11.1. Functions of Nucleic Acids -- 11.2. Infectivity -- 11.3. Transformation -- 11.4. Priming Activity of DNA -- 11.5. Enzyme Induction -- 11.6. DNA-mRNA Hybrids -- 11.7. Translation -- References -- 12. The Action of Radiation on Viruses -- 12.1. Basic Properties of Viruses -- 12.2. Inactivation of Viruses containing Single-Stranded Nucleic Acids -- 12.3. Inactivation of Viruses containing Double-Stranded DNA -- 12.4. Repair of Radiation Damage in Viral DNA -- 12.5. BU Effect -- References -- 13. The Action of Radiation on Bacteria -- 13.1. Some Basic Properties of Bacteria -- 13.2. Inactivation of Bacteria -- 13.3. Bacterial DNA as the Critical Target -- 13.4. Repair of UV Damage -- 13.5. Repair of Damage caused by Ionizing Radiation -- 13.6. Genetic Control of Repair in Bacterium E. coli -- 13.7. Micrococcus Radiodurans -- References -- 14. Radiation Sensitivity and Biological Complexity -- 14.1. Attempts at a Systematic Approach -- 14.2. What is Radiation Sensitivity? -- References.
Keywords: Life sciences; Medicine; Life Sciences, general; Biomedicine, general