Quantitative Aspects of Chemical Pharmacology Chemical Ideas in Drug Action with Numerical Examples - Barlow, R.B.; SpringerLink (Online service) (New York, NY : Springer US : Imprint: Springer, 1980)
1. Measuring Drug Activity -- Measuring the Effects of Drugs: 'Responses' -- Assessing Biological Activity -- Application of Bioassay Methods to the Comparison of Drugs -- Types of Drug Action -- 2. Physicochemical Problems -- Rates of Reaction and Positions of Equilibrium -- Solubility -- Volume of Dilution -- Rate of Removal -- Rate of Absorption -- Partition Coefficients and Crossing Membranes -- Relations between Reaction Rates and Equilibrium Constants -- 3. The Size and Shape of Molecules -- Size: Molal Volumes and Apparent Molal Volumes -- Shape -- Isomerism -- Optical Rotation -- Stereochemical Purity and Biological Activity -- Description of the Arrangements of Groups about an Asymmetric Carbon Atom -- Preferred Conformations -- 4. Chemical Processes where Size and Shape are Important -- Adsorption -- Adsorption of Two Species -- Enzyme and Substrate -- The Need for Other Models -- Agonists and Receptors -- Rate Theory -- Desensitisation of Receptors -- Forces between Drug and Receptor -- 5. The Prediction of Drug Activity -- Nonspecific Activity -- Homologous Series -- Biological Activity and Chemical Properties: the Ideas of Hansch -- Is Affinity Predictable? -- Conclusion -- Appendix: Line-fitting by the method of least-squares -- Answers to Examples.
Keywords: Pharmacology; Pharmacology/Toxicology.; Science, Humanities and Social Sciences, multidisciplinary