High-Throughput Screening Assays in Toxicology - Zhu, Hao.; Xia, Menghang; SpringerLink (Online service) (New York, NY : Springer New York : Imprint: Humana, 2016)
Monitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay -- Mitochondrial Membrane Potential Assay -- Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway -- Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators -- Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity -- Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway -- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells -- Determination of Histone H2AX Phosphorylation in DT40 Cells -- High-Throughput and High Content Micronucleus Assay in CHO-K1 Cells -- Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish -- Fast Functional Germline and Epigenetic Assays in the Nematode <Caenorhabditis elegans -- A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling -- Correction of Microplate Data from High-Throughput Screening -- CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints -- Accounting Artifacts in High-Throughput Toxicity Assays -- Accessing the High-Throughput Screening Data Landscape -- Curating and Preparing High Throughput Screening Data for Quantitative Structure Activity Relationship Modeling.
Keywords: Pharmacology; Pharmacology/Toxicology.