Introduction to Systems Biology - Choi, Sangdun; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2007)
Scientific Challenges in Systems Biology -- Bringing Genomes to Life: The Use of Genome-Scale In Silico Models -- From Gene Expression to Metabolic Fluxes -- Experimental Techniques for Systems Biology -- Handling and Interpreting Gene Groups -- The Dynamic Transcriptome of Mice -- Dissecting Transcriptional Control Networks -- Reconstruction and Structural Analysis of Metabolic and Regulatory Networks -- Cross-Species Comparison Using Expression Data -- Methods for Protein-Protein Interaction Analysis -- Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution -- Location Proteomics -- Theoretical and Modeling Techniques -- Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models -- Modeling Spatiotemporal Dynamics of Multicellular Signaling -- Kinetics of Dimension-Restricted Conditions -- Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction -- Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space -- Dynamic Instabilities Within Living Neutrophils -- Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology: ? Switch as a Working Example -- Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath Project -- Methods and Software Platforms for Systems Biology -- SBML Models and MathSBML -- CellDesigner: A Graphical Biological Network Editor and Workbench Interfacing Simulator -- DBRF-MEGN Method: An Algorithm for Inferring Gene Regulatory Networks from Large-Scale Gene Expression Profiles -- Systematic Determination of Biological Network Topology: Nonintegral Connectivity Method (NICM) -- Storing, Searching, and Disseminating Experimental Proteomics Data -- Representing and Analyzing Biochemical Networks Using BioMaze.
Keywords: Life sciences; Pharmacology; Cell biology; Biochemistry; Microscopy; Developmental biology; Life Sciences, general; Pharmacology/Toxicology.; Cell Biology; Biochemistry, general; Biological Microscopy; Developmental Biology