Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy Molecular Mechanisms and Clinical Applications - Bonetti, Andrea; Leone, Roberto; Muggia, Franco; Howell, Stephen B.; SpringerLink (Online service) (Totowa, NJ : Humana Press : Imprint: Humana, 2009)
Novel Platinum Analogues, Original Formulations and Other Heavy Metals -- Platinum Compounds: The Culmination of the Era of Cancer Chemotherapy -- Studies on New Platinum Compounds -- Assessment of the In Vivo Antiproliferative Activity of a Novel Platinum Particulate Pharmacophore -- Nanocapsules of Platinum-Based Anticancer Drugs -- The Design and Development of the Tumor-Targeting Nanopolymer Dach Platinum Conjugate AP5346 (Prolindac™) -- In vitro Anti-proliferative Effects of ProLindac™, a Novel Dach-Platinum-Linked Polymer Compound, as a Single Agent and in Combination with Other Anti-cancer Drugs -- Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes -- Ruthenium Drugs for Cancer Chemotherapy: An Ongoing Challenge to Treat Solid Tumours -- X-ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex -- Osmium Arenes: A New Class of Potential Anti-cancer Agents -- Cellular Transport and Intracellular Trafficking of Platinum Compounds -- Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells -- CTR1 as a Determinant of Platinum Drug Transport -- Regulation of the Export of Platinum-Containing Drugs by the Copper Efflux Transporters ATP7A and ATP7B -- Altered Localization of Transport Proteins Associated with Cisplatin Resistance -- How to Overcome Cisplatin Resistance Through Proton Pump Inhibitors -- Cellular Resistance to Oxaliplatin and Drug Accumulation Defects -- Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action -- DNA Damage and Signal Transduction: Recognition/Repair And Cell-Response -- Structural and Mechanistic Studies of Anticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding -- Platinum Drugs and DNA Repair: Lessons from the NCI Panel and Clinical Correlates -- Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts -- Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest -- Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy -- CHK2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance -- Modulation of Survival Pathways in Ovarian Carcinoma Cells Resistant to Platinum Compounds -- Paraptotic Cell Death Induced by the Thioxotriazole Copper Complex A0: A New Tool to Kill Apoptosis-Resistant Cancer Cells -- Clinical Applications -- Platinum Compounds and Radiation -- Treating Cisplatin-Resistant Cancer: A Systematic Analysis of Oxaliplatin or Paclitaxel Salvage Chemotherapy -- Platinum Compounds in Lung Cancer: Current Status -- Is Lipoplatinum Monotherapy an Active Alternative in Second Line Treatment of Metastatic Non-Small Cell Lung Cancer? A Phase II Trial -- Combining Platinums in Gastric Cancer -- Oxaliplatin-Based Chemotherapy for Colon Cancer -- First-Line Systemic Chemotherapy with Folfoxiri Followed by Radical Surgical Resection of Metastases for the Treatment of Unresectable Metastatic Colorectal Cancer Patients -- Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin -- The Role of Platins in Newly Diagnosed Endometrial Cancer -- Platinum Compounds: Key Ingredients in Ovarian Cancer Treatment and Strategies -- Intraperitoneal Chemotherapy: An Important Strategy in Ovarian Cancer Treatment -- Novel Strategies for Enhancing the Efficacy of Intraperitoneal Chemotherapy for Patients with Ovarian Cancer -- Laparoscopically Assisted Heated Intra-Operative Intraperitoneal Chemotherapy (HIPEC): Technical Aspect and Pharmacokinetics Data -- Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity -- Peripheral Neurotoxicity of Platinum Compounds -- Platinum Drugs in Children with Cancer -- Optimising Carboplatin Dose using Patient Characteristics and Therapeutic Drug Monitoring.
Keywords: Cancer research; Pharmacology; Cancer Research; Pharmacology/Toxicology.