Protein-Protein Interactions as New Drug Targets - Klussmann, Enno.; Scott, John.; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2008)
Organization of Scaffolds -- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling -- Arrestins as Multi-Functional Signaling Adaptors -- Role of Ena/VASP Proteins in Homeostasis and Disease -- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy -- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? -- Scaffolding Proteins and Cellular Signalling -- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases -- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains -- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design -- Compartmentalised MAPK Pathways -- Dynamic Protein Complexes Regulate NF-?B Signaling -- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics -- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling -- Cell Type-Specific Anchoring -- Scaffolding Proteins in Cardiac Myocytes -- Molecular Architecture of Signal Complexes Regulating Immune Cell Function -- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework -- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept -- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies -- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition -- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors -- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs -- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets.
Keywords: Pharmacology; Cell biology; Medical biochemistry; Molecular biology; Pharmacology/Toxicology.; Cell Biology; Medical Biochemistry; Molecular Medicine