Quantitative Biology of Metabolism Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control - Locker, Alfred; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1968)
1. Models of Metabolism -- 1.1. Models in General -- 1 The Epistemological Significance of Models in Science -- 2 Causality, Complexity and Computers -- 1.2. Discrete and Continuous Models -- 3 Discrete and Continuous Representations of Metabolic Models -- 4 Interaction of a Digital (Genetic) System with a Continuous (Enzymatic) One in the Cell -- 5 A Model for Sustained Rhythmic Binary Logic in Biochemical Systems -- 1.3 Stochastic and Deterministic Models -- 6 Some General Ideas on Deterministic and Stochastic Models in Biological Systems -- 7 Turnover Compartmentalization. An Approach to Analysis of Whole-body Retention Data -- 1.4 Computer Models of Cell Metabolism -- 8 Functioning of a Cell Model -- 9 A Digital Computer System for the Construction and Analysis of Steady State Models of Enzyme Catalysed Networks -- 10 Computation of Equilibria and Kinetics of Chemical Systems with Many Species -- 2. Metabolic Parameters -- 2.1 Temperature - Season - Adaptation -- 11 The Relation between Heat Production, Oxygen Consumption and Temperature in Some Poikilotherms -- 12 On Structure and Metabolic Rate of the Skeletal Muscle of the Eel (Anguilla vulgaris L.) -- 13 Analysis of Heart Rate Adaptation to Temperature -- 14 The Heat Production of Goldfinches and Canaries in Summer and Winter -- 15 Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation -- 2.2 Growth - Age -- 16 Contributions to the Energetics of Animal Growth -- 17 Models of the Growth of Organisms under Nutrient Limiting Conditions -- 18 Biomathematical Interpretation of Organismic Growth -- 19 Relationships between Respiration during Imbibition and Subsequent Growth Rates in Germinating Seeds -- 20 Quantitative Parameters of Rat Liver Mitochondria in Relation to Age -- 2.3 Cellular Milieu - Experimental Influences -- 21 Enzymes as Indicators of Intracellular Reaction Conditions -- 22 The Influence of Ethanol on Carbohydrate- and Fat-Metabolism of the Liver -- 3. Damage to Metabolism -- 3.1 Damage Due to Irradiation -- 23 Application of Quantitative Models for the Analysis of the Mechanisms of Protection against the Damaging Effects of Ionizing Radiation -- 24 Intracellular Recovery after Irradiation -- 3.2 Damage Due to Radio lytic or Toxic Compounds -- 25 Inhibitory Action of Radiolytic Compounds on Cell Function -- 26 On the Release and Elimination of Liver Glutamic-Oxalacetic-Transferase -- 3.3 Damage Due to Oxygen Lack -- 27 Metabolic Effects of Acute Hypoxia on Rat and Turtle Brain -- 28 Changes in Metabolite Concentrations in Ischemic Kidneys of Rabbits and in Transplanted Kidneys of Dogs -- 4. Metabolic Control -- 4.1 Metabolic Control and Optimisation -- 29 The Mutual Coaction of two Regulatory Mechanisms Realizing Optimal Autoregulation of Metabolism -- 30 Optimization of Structure and Metabolism in Cellular Automata -- 4.2 Metabolic Control at the Cellular Level -- 31 Oscillatory Control of Glycolysis as a Model for Biological Timing Processes -- 32 Evaluation of the Coordinated Control of Activated Glycolysis and Respiration by Ortho-phosphate and ADP in Ascites Tumor Cells -- 33 Profiles of Substrate Levels of the Central Metabolic Pathways in Frog Heart -- 4.3 Control at the Systemic Level -- 34 Analysis by Computer of Some Oscillatory Features of the Red Cell System -- 4.4 Control and CNS -- 35 Memory and Cellular Control Processes -- 36 On the Steady State Nature of Evolution, Learning, Perception, Hallucination and Dreaming -- 37 Circadian Activity Rhythm in the CNS and its Control -- 4.5 Thermoregulation -- 38 The Use of Theoretical Models in the Study of Thermoregulation in Man -- 39 On the Mechanism of the Calorigenic Action of Catecholamines -- 5. Conclusion -- 40 Some Epicritical Remarks (Instead of a Summary) -- Author Index.
Keywords: Metabolism; Biochemistry; Systems biology; Metabolomics; Animal Biochemistry; Systems Biology