Clinical Pharmacology in the Elderly Reference Ranges and Biological Variations After Repeated Measurements - Breuel, Hans-Peter.; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1996)
1 Introduction -- 2 Theories of Aging -- 3 Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age -- 3.1 Changes in Central Nervous System -- 3.2 Cardiovascular and Pulmonary Changes -- 3.3 Changes in Clinical Chemistry and Hematology -- 3.4 Changes in Pharmacokinetics -- 3.5 Changes in Receptor Sensitivity -- 4 Practical Aspects in Performing Clinical Trials in Elderly Subjects -- 4.1 Recruitment of Subjects -- 4.2 Performance of the Study -- 4.3 Safety Aspects -- 4.4 Sample Size -- 4.5 Compliance of Subjects with Medication and Study Regulations -- 5 Experimental Findings in Elderly Subjects -- 5.1 Method -- 5.2 Experimental Data -- 5.3 Consequences from Experimental Data in Healthy Subjects -- 6 Statistical Details -- 6.1 Blood Pressure -- 6.2 Ambulatory Blood Pressure Monitoring -- 6.3 ECG Times -- 6.4 Ambulatory ECG Monitoring -- 6.5 Spirometry (FEV1) -- 6.6 Clinical Chemistry -- 6.7 Hematology -- References.
Keywords: Pharmacology; Internal medicine; Pharmacology/Toxicology.; Internal Medicine