Principles of Peptide Synthesis - Bodanszky, Miklos; SpringerLink (Online service) (Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1993)
I. Introduction -- References -- II. Activation and Coupling -- 1 Activation -- 2 Coupling -- 3 Coupling Methods -- References -- III. Reversible Blocking of Amino and Carboxyl Groups -- 1 General Aspects -- 2 Protection of the Carboxyl Group -- 3 Protection of the Amino Group -- References -- IV. Semipermanent Protection of Side Chain Functions -- 1 Carboxyl Groups of Aspartyl and Glutamyl Residues -- 2 Side Chain Amino Groups of Lysine and Ornithine -- 3 Hydroxyl Groups in Serine, Threonine and Tyrosine -- 4 The Sulfhydryl Group in Cysteine -- 5 The Guanidino Group of Arginine -- 6 Imidazole in Histidine -- 7 The Thioether in Methionine -- 8 The Indole Nitrogen in Tryptophan -- 9 The Carboxamide Groups in Asparagine and Glutamine -- References -- V. Side Reactions in Peptide Synthesis -- 1 Side Reactions Initiated by Proton Abstraction -- 2 Side Reactions Initiated by Protonation -- 3 Side Reactions Due to Overactivation -- 4 Side Reactions Related to Individual Amino Acid Residues -- References -- VI. Tactics and Strategy in Peptide Synthesis -- 1 Tactics -- 2 Strategies -- 3 Disulfide Bridges -- 4 Synthesis of Cyclic Peptides -- 5 Sequential Polypeptides -- 6 Partial Synthesis (Semisynthesis) -- References -- VII. Techniques for the Facilitation of Peptide Synthesis -- 1 Solid Phase Peptide Synthesis (SPPS) -- 2 Synthesis in Solution -- References -- VIII Recent Developments, New Trends -- 1 Formation of the Peptide Bond -- 2 Protecting Groups -- 3 Solid Phase Peptide Synthesis -- 4 Undesired Reactions in Peptide Synthesis -- 5 New Trends and Perspectives -- References.
Keywords: Biochemistry; Artificial intelligence; Organic chemistry; Biochemistry, general; Artificial Intelligence; Organic Chemistry