Prion Diseases Diagnosis and Pathogenesis - Groschup, Martin H.; Kretzschmar, Hans.; SpringerLink (Online service) (Vienna : Springer Vienna : Imprint: Springer, 2000)
Pathogenesis of Prion Diseases -- Prions: from neurografts to neuroinvasion -- Follicular dendritic cells in scrapie pathogenesis -- Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep -- Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice -- Pathogenesis of natural scrapie in sheep -- Animal Models for Priorn Diseases -- Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPC -- Analyzing the influence of PrP primary structure on prion pathogenesis in transgenic mice -- A single amino acid alteration in murine PrP dramatically alters TSE incubation time -- A transgenic model of a familial prion disease -- Transgenic models of prion disease -- Epidemiology and Diagnosis of Prion Diseases -- Surveillance of BSE -- Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs) -- Pathology of variant Creutzfeldt-Jakob disease -- Clinical and differential diagnosis of Creutzfeldt-Jakob disease -- Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases -- Detection of PrPSc in subclinical BSE with the paraffin-embedded tissue (PET) blot -- Sheep and goats: natural and experimental TSEs and factors influencing incidence of disease -- Application of Prionics Western blotting procedure to screen for BSE in cattle regularly slaughtered at Swiss abattoirs -- Specific determination of the proteinase K-resistant form of the prion protein using two-site immunometric assays. Application to the post-mortem diagnosis of BSE -- Characterization of the Infectious Agent -- PrPSc typing by N-terminal sequencing and mass spectrometry -- Characterization of BSE and scrapie strains/isolates -- Quantitative traits of prion strains are enciphered in the conformation of the prion protein -- Structure and Function of PrP -- Function of PrPc as a copper-binding protein at the synapse -- The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations -- Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro -- PrP Conversion -- Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs -- The use of monoclonal antibody epitopes for tagging PrP in conversion experiments -- Listed in Current Contents.
Keywords: Virology; Pathology; Virology; Pathology