Combined Effects of Drugs and Toxic Agents Modern Evaluation in Theory and Practice - Pöch, Gerald; SpringerLink (Online service) (Vienna : Springer Vienna : Imprint: Springer, 1993)
1 Principle considerations of drug actions and interactions -- 1.1 Introduction -- 1.2 Dose-response curves -- 1.3 Time course of effects -- 1.4 Phenomena and mechanisms: interactions between drugs - antagonism and synergism -- 2 Concepts and models of interactions - additivity and independence -- 2.1 Concept and phenomenon of additivity -- 2.2 Site-directed analysis -- 2.3 Concept of independence -- 2.4 Relationship between additivity and independence -- 2.5 Summary and conclusions -- 2.6 Tips and hints -- 3 Synergism/potentiation and antagonism - phenomena and mechanisms -- 3.1 The current dilemma -- 3.2 Towards a uniform characterization of synergism/potentiation and antagonism -- 3.3 Potentiation (synergism) -- 3.4 Antagonism -- 3.5 Comparison of complex with simple interactions -- 3.6 Quantitative expression of combined effects -- 3.7 Suggestions for quantitation of combined effects -- 3.8 Tips and hints -- 4 Evaluation by dose-response curves -- 4.1 New methodological approach: fixed-dose studies -- 4.2 Fixed dose-ratio combinations -- 4.3 Tips and hints -- 5 Evaluation by time-course studies -- 5.1 Time course of independent actions -- 5.2 Dose-additive time course -- 5.3 Statistical comparison of observed and expected time course -- 5.4 Time-course studies with log response scale -- 5.5 Comparison of time-course studies and dose-response studies -- 5.6 Conclusions -- 6 Single-dose and other studies -- 6.1 Single-dose studies -- 6.2 Other studies -- 7 Combined-effect graph and other graphs -- 7.1 The construction of the combined-effect graph -- 7.2 Comparison of observed with independent effects -- 7.3 Yonetani-Theorell plot for enzyme inhibitors -- 7.4 Tips and hints -- 8 Applications of the new approach and observations -- 8.1 Biochemistry and physiology/pathophysiology -- 8.2 Experimental pharmacology -- 8.3 Clinical pharmacology - drug combinations -- 8.4 Chemotherapy of infections and tumors -- 8.5 Experimental and environmental toxicology -- 8.6 Epidemiology - risks -- 8.7 Herbicides -- 8.8 Conclusions and discussion -- 9 A new and critical view of isobolograms -- 9.1 Inappropriate conclusions -- 9.2 Pitfalls -- 10 Comparison of the new with the conventional approach -- 10.1 Experimental dose-response curves and isobolograms -- 10.2 Evaluation of combined effects in the future -- Epilog -- Appendix A - Glossary of terms and abbreviations -- Appendix B - Guide to practical work: exercise examples -- References.
Keywords: Pharmacology; Anesthesiology; Endocrinology .; Immunology; Virology; Oncology .; Pharmacology/Toxicology.; Anesthesiology; Endocrinology; Immunology; Virology; Oncology