The Immune Synapse as a Novel Target for Therapy - Graca, Luis.; SpringerLink (Online service) (Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2008)
The immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.
Keywords: Immunology; Infectious diseases; Cell biology; Molecular biology; Pharmacology; Allergy; Immunology; Infectious Diseases; Cell Biology; Molecular Medicine; Pharmacology/Toxicology.; Allergology